In this study, Spearman rank correlation analysis showed that LRP1 was positively correlated with NT-proBNP and cTnT and negatively correlated with LVEF value, indicating that arterial LRP1 could reflect myocardial ischemia degree, ventricular wall tension, and cardiac systolic function in the early STEMI period to a certain extent. This evidence concerns the gene NPPB and myocardial ischemia.