Combined administration of monophosphoryl lipid A (MPLA) and IFN-γ stimulates type I IFN signaling in breast cancer, which reprogramed CD206+ TAMs to iNOS+ TAMs, resulting in cytotoxic T cell activation through macrophage-secreted IL-12 and TNF-α, finally reduction of primary tumor growth and metastasis 209. This evidence concerns the gene TNF and neoplasm.