Recruitment of CD8+ T cells was blocked by TAMs in TME of HCC through the inhibition of CXCL9 and CXCL10, meanwhile CD8+ T cell activation and proliferation were attenuated through regulating L-arginine by ARG1 and inducible NO synthase (iNOS) in lung cancer and lymphoma 44, 148. This evidence concerns the gene NOS2 and hepatocellular carcinoma.