SPP1 and neoplasm: Spatial and single-cell analysis of human normal and cancer colorectal tissues elucidate co-localization of cancer cell with SPP1 + TAMs at the invasive front of tumor, where CRC cell secrets human leukocyte antigen G (HLA-G) to transform TAMs into macrophages with immunosuppressive feature and reduces cytotoxicity of ICB immunotherapy 63.