For example, TAMs promoted stem cell-like properties of cancer cells by activating the nuclear transcription factor-κB (NFκB) pathway in colon cancer and breast cancer, the IL-6-STAT3 (Signal transducer and activator of transcription 3) pathway in HCC and the AKT-mTOR pathway in RCC 99. Here, STAT3 is linked to malignant colon neoplasm.