Overexpression of BRD7 could inhibit NPC cell proliferation, block the G1 to S phase cell cycle progression through the Ras/MEK/ERK, PI3K/AKT, and Rb/E2F signaling pathways, induce cell apoptosis, and reverse the malignant phenotype of NPC cells 28-31. Here, AKT1 is linked to nasopharyngeal carcinoma.