Additionally, overexpression of ZNF217 in paclitaxel-treated MDA-MB-231 breast cancer cells induces resistance to apoptosis by downregulating pro-apoptotic proteins (Bad, Bak, Bax) and upregulating anti-apoptotic proteins (Bcl-2, Bcl-XL) 47. The gene discussed is BAK1; the disease is breast carcinoma.