PPARGC1A and hepatocellular carcinoma: Peroxisome proliferator-activated receptor-gamma coactivator-1α (PPARGC1A) was down-regulated in lenvatinib-resistant HCC cells, and under hypoxia, overexpression of PPARGC1A improved sensitivity to ferroptosis and counteracted LR by controlling bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI)/ACSL5 signaling 80.