As mentioned earlier, overexpressed FGFR1 together with activated AKT/mTOR and ERK pathways could induce LR in HCC, and oxysophocarpine could reduce the expression of FGFR1 and concurrently suppress the downstream signaling, thereby enhancing the sensitivity of lenvatinib 26. This evidence concerns the gene FGFR1 and hepatocellular carcinoma.