Further experiments found that TMX2 relieved LR and amplified the anti-tumor impact of lenvatinib in HCC by suppressing autophagy and mitophagy, which was achieved through the inhibition of karyopherin subunit beta (KPNB) 1's nuclear export and transcription factor EB (TFEB) 's nuclear import. The gene discussed is TMX2; the disease is hepatocellular carcinoma.