Our previous study revealed that phosphorylated non-muscle myosin heavy chain 9 (p-MYH9) at Ser1943, could deubiquitinate and stabilize HIF-1α by recruiting (ubiquitin-specific protease 22) USP22 in HCC, which led to the development of LR 15. The gene discussed is MYH9; the disease is hepatocellular carcinoma.