Using CRISPR-Cas9 screen along with database analysis, Pan et al. pinpointed lysosomal protein transmembrane 5 (LAPTM5) as a crucial contributor to LR in HCC, and discovered that LAPTM5 could enhance the intrinsic autophagic flux by promoting the formation of autolysosomes 48. This evidence concerns the gene LAPTM5 and hepatocellular carcinoma.