In addition, sunitinib sensitivity assays displayed that LCOR overexpression noticeably increased the sensitivity of A498 and CAKI cells to sunitinib (Fig. S7A), whereas the high sensitivity of ccRCC to sunitinib elicited by LCOR overexpression could be obviously reversed by PLCL1 knockdown (Fig. S7B). Here, LCOR is linked to nonpapillary renal cell carcinoma.