Overall, our meta-analysis not only confirms the high variability in EndMT-related markers but also establishes a possible statistical correlation between EndMT and lung cancer, remarking the downregulation of CLDN11 and poor prognosis, alongside the upregulation of ANGPT2 with its possible role as a potential biomarker in esophageal carcinoma. The gene discussed is CLDN11; the disease is lung cancer.