In addition, microsomal glutathione S-transferase 1 (MGST1), a membrane-bound transferase located mainly in mitochondria, the endoplasmic reticulum (ER), the plasma membrane, and peroxisomes that plays a clear role in the conjugation of electrophiles and oxidative stress protection, has also been reported to bind to ALOX5, limiting ALOX5-mediated lipid peroxidation and subsequent ferroptosis in an Nrf2-dependent manner in pancreatic cancer cells105. This evidence concerns the gene ALOX5 and familial pancreatic carcinoma.