HO-1 plays an essential role in clear cell renal cell carcinoma cell ferroptosis, and the mechanism involves the release of free iron mediated by HO-1-induced heme degradation, contributing to the generation of oxidized lipids in the mitochondrial membrane136, and it can be increased by the nuclear translocation of Nrf2114. This evidence concerns the gene HMOX1 and clear cell renal carcinoma.