PRKN and non-small cell lung carcinoma: Researchers found that cytochrome c oxidase subunit 7a (COX7A1), an important complex in the mitochondrial ETC, increased the sensitivity of NSCLC cells to CDI ferroptosis, accompanied by the downregulation of PINK, Parkin, PGC-1α (mitochondrial biogenesis activator), TFAM, DRP1, and MFN1, indicating its inhibition of mitochondrial biogenesis, mitophagy, and mitochondrial fusion and fission82.