2,4-Dienoyl-CoA reductase 1 (DECR1) is the rate-limiting enzyme in a PUFA β oxidation auxiliary pathway, and its knockdown induces the significant accumulation of phospholipid hydroperoxides, increases the levels of mitochondrial oxidative stress, and induces ferroptosis in prostate cancer cells162. This evidence concerns the gene DECR1 and Familial prostate cancer.