Inhibition of LONP1 expression induces the activation of the Nrf2/Keap1 signaling pathway and GPX4 expression, and the ability of LONP1 to mediate the degradation of substrates involved in mitochondrial biogenesis induce mitochondrial DNA (mtDNA) stress and ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cells43, 44. This evidence concerns the gene LONP1 and pancreatic ductal adenocarcinoma.