PRKAA1 and cancer: However, AMPK activators and DHODH inhibitors can synergistically induce ferroptosis in cancer cells; thus, the active AMPK-promoted pyrimidinosome-mediated ferroptosis defense appears to serve as a protective pathway to prevent self-jury, and the DHODH-mediated metabolic conversion potentially plays a key role in antagonizing AMPK-related stresses99.