Beyond handling cholesterol levels in the cell, SREBP1-dependent regulation of transforming growth factor beta (TGF-β) expression, TGF-β receptor activation, induction of a canonical mothers against decapentaplegic homologs 2/3 (SMAD2/3) effector cascade in pancreatic cancer 31, epithelial-mesenchymal transition activation, and induction of E2F transcription factor 1 (E2F1) expression 32 have been demonstrated. The gene discussed is SMAD2; the disease is familial pancreatic carcinoma.