CPS1 and Anxiety: However, measurement of entry to the center during the first 5 min (Figure 5F), a sign of lower anxiety-like behavior, was reduced in AAV8.CPS1-treated mice (males, 25.625 ± 8.123 center entries vs. 8.067 ± 3.055 center entries, [p = 0.0025]; Cps1 wild-type control vs. AAV treated respectively; females, 24.875 ± 4.643 center entries vs. 12.875 ± 9.387 center entries, [p = 0.0035]; control vs. AAV treated respectively) who spend more time in the periphery than the center (Figure 5G) (purple = periphery; green = center), indicating an anxiety-like phenotype.