This conclusion is supported by the finding that IgG, purified from the sera of patients with medium–high titers of anti-β2GPI antibodies, were able to induce thrombus formation in a rat model of APS and that the prothrombotic effect was prevented by the depletion of anti-β2GPI antibodies via affinity chromatography (7). Here, APOH is linked to autoimmune polyendocrinopathy.