found that compared with healthy controls, Th1 cells in the synovial fluid (SF) of RA patients had higher levels of GADD45β and lower apoptotic rate; more importantly, GADD45β RNAi can reverse the resistance of Th1 cells to apoptosis, confirming the anti-apoptotic effect of GADD45β in Th1 cells (149) (Figure 3). The gene discussed is GADD45B; the disease is rheumatoid arthritis.