Furthermore, two single nucleotide polymorphisms (SNPs) of GADD45 have been identified as associated with autoimmune diseases, namely, the GADD45α 589GG+GC is linked with rheumatoid factor (RF), and the GADD45β -712CT genotypes are related to anti-RNP antibodies in SLE patients (29). This evidence concerns the gene GADD45A and autoimmune disease.