GADD45G and Ureteral obstruction: Adenovirus-mediated expression of GADD45γ in cultured renal tubular cells activated p38 and significantly upregulates chemokine ligands and fibrosis-related factors; silencing the expression of GADD45γ significantly blunted the inflammatory and fibrotic mediators and monocyte infiltration in the kidneys of rats with ureteral obstruction (129) (Figure 3).