GADD45α was upregulated in peripheral CD4+ T cells of psoriasis patients, especially the infiltrating T cells in the dermis of damaged skin, but the level of GADD45α was lower in the epidermal cells; GADD45β also exhibited a similar expression pattern to GADD45α in the patients with psoriasis; in addition, the expression of GADD45α positively correlated with IFN-γ and TNF-α in the affected skin of psoriasis patients, a positive correlation was also observed between GADD45β and TNF-α (156). Here, CD4 is linked to psoriasis.