Recent research indicates that in cerebral ischemia/reperfusion (I/R) injury, COG1410, an agonist of Low-density lipoprotein receptor-related protein-1 (LRP1), inhibits the TXNIP/NLRP3 signaling pathway and promotes the shift in microglial polarization from the M1 phenotype to the M2 phenotype, thereby contributing to anti-inflammatory effects (91). The gene discussed is LRP1; the disease is brain ischemia.