Within hypoxic-ischemic encephalopathy (HIE), transient receptor potential vanilloid 1 (TRPV1) intensifies astrocyte activation and promotes the secretion of IL-1β by astrocytes via the JAK2-STAT3 signaling pathway and activation of NLRP3 inflammasomes (56). This evidence concerns the gene JAK2 and perinatal asphyxia.