The present study showed that children with comorbid asthma and obesity/overweight had higher IL-6, TNF-α, and leptin, and lower 25-(OH) D3, IL-10, and IL-13 than children with asthma alone, and had lower IL-10 and higher IL-6, IL-13, and leptin than children with obesity/overweight alone. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.