The IL-12/IFN-γ-related Inborn Errors of Immunity (IEIs) in children, such as those with Mendelian Susceptibility to Mycobacterial Disease (MSMD), render individuals highly susceptible to severe mycobacterial infections and salmonellosis, highlighting the critical role of the IL-12/IFN-γ axis in defending intracellular pathogens (5). This evidence concerns the gene IFNG and Mendelian susceptibility to mycobacterial diseases.