In another example, we have recently used deep neural networks including AlphaFold2 and RoseTTAFold to model the interaction between kidney injury molecule 1 (KIM1, also known as HAVCR1) and death receptor 5 (DR5), top-scored antagonistic peptides derived from human KIM1/DR5 based on predicted binding sites significantly blocked KIM1-DR5 interaction and exhibited reno-protection effects against acute kidney injury in vitro and in vivo (Yang et al., 2021; Yang C. et al., 2023). Here, TNFRSF10B is linked to acute kidney injury.