,90 SQSTM1 is highly expressed in BC and plays an essential role in BC development,91 and USP8 can regulate SQSTM1 degradation and autophagy by deubiquitylating SQSTM1 at the K420,92 which has been shown to play a vital role in autophagosomal formation and autophagic flux.93 This evidence concerns the gene SQSTM1 and breast cancer.