USP35 and neoplasm: The mechanisms by which USPs are associated with PCD in tumor cell development were also elucidated, e.g., inhibition of USP1 induces apoptosis and autophagy in hepatocellular carcinoma66; depletion of USP35 increases sensitivity to cisplatin-induced apoptosis in NSCLC67; and USP35 can stabilize the RRS in NSCLC cells by RRBP1 to mitigate endoplasmic reticulum (ER) stress-induced apoptosis.68