To investigate the potential role of EGFR in the distribution of proliferating hepatocytes during the early stages of PVL-induced LR, we first examined the expression of EGFR in human liver tissue using an online database (https://www.proteinatlas.org) and found that its expression was relatively higher in hepatocytes in zone 1 and zone 2, and relatively lower in zone 3 (Fig. S11). Here, EGFR is linked to periventricular leukomalacia.