APOE and glioblastoma: ,128 In glioblastoma, ELF4 regulates the expression of genes associated with both receptor tyrosine kinase (RTK) signaling (SRC, protein tyrosine kinase 2 beta (PTK2B), and tyrosine kinase non-receptor 2 (TNK2)) and lipid dynamics (LDL receptor-related protein 1 (LRP1), apolipoprotein E (APOE), ATP binding cassette subfamily A member 7 (ABCA7), phospholipase A2 group VI (PLA2G6), and phosphatidylinositol transfer protein membrane-associated 2 (PITPNM2)), thereby promoting cancer cell proliferation.129