In the case of alcoholic liver disease, Zhong et al reported that Gly-tRFs are regulated by CYP2E1 (cytochrome P450 2E1) in animal models, and the Gly-tRFs/AGO3/Sirt1 (sirtuin 1) axis may ultimately influence chronic liver steatosis.28 The gene discussed is SIRT1; the disease is alcoholic liver diseases.