A prominent mechanism of immune evasion in EC revolves around the up-regulation of immune checkpoint molecules, with a particular emphasis on PD-L1 on the surfaces of cancer cells.78, 79, 80 The study has underscored the association between high PD-L1 expression in EC and an unfavorable prognosis, elucidating the significance of this checkpoint molecule in the realm of immune evasion.80 The gene discussed is CD274; the disease is cancer.