The down-regulation of miRNA-615 and attenuation of its inhibitory effect on hepatocyte nuclear factor-1β (HNF-1) caused by the overexpression of lncRNA4474 may delay the course of renal fibrosis, and miRNA-615 could activate the Wnt pathway by suppressing HNF-1.147. The gene discussed is HNF1A; the disease is renal fibrosis.