NFE2L2 and kidney disorder: Overexpression of lncRNA ENST00000453774.1 could promote reactive oxygen species defense via nuclear factor erythroid 2-related factor (Nrf2)-keap1/heme oxygenase 1 (HO-1)/NAD (P)H: quinone oxidoreductase 1 (NQO-1) signaling by inducing prosurvival autophagy, and then reduce extracellular matrix-related proteins (e.g., collagen I and fibronectin), which can be a new anti-fibrotic treatment for kidney diseases.151