Building upon our current and previous findings showing that TGF‐β is a strong inducer of senescence in epithelial HCC cell lines [12], but not in mesenchymal HCC cell lines [17], we decided to expose the epithelial Huh7 and Hep3B cell lines to chronic TGF‐β treatment. Here, TGFB1 is linked to hepatocellular carcinoma.