Moreover, given that the rs6679677 SNP is associated with other indications beyond JIA, such as type 1 diabetes,38 rheumatoid arthritis,39 and systemic lupus erythematosus,40 it is possible that HIPK1 inhibition in the context of treating HTC may result in immune-modulated adverse reactions beyond synovial joints in other tissues, such as the pancreas. Here, HIPK1 is linked to systemic lupus erythematosus.