The following genes were identified as key differential genes from the drug database CMAP and key disease subtypes: MAP3K2, CALM1, MAP2K2, FKBP1A, MAPK1, etc. A search was conducted for relevant drugs that can inhibit the expression of these genes, resulting in the identification of Axitinib, Sirolimus, Perphenazine, etc. This suggests that the automated annotation tool, gPRINT, can greatly improve the efficiency and accuracy of annotation of fibroblast subtype labels, thus advancing the research and therapeutic process of tendinopathy. This evidence concerns the gene MAPK1 and disease of the tendon.