It has been shown that orexin‐A in the spinal cord activates the micturition reflex in normal rats (Kobayashi et al., 2009) and that antagonism of orexin 2 receptors in rats with induced overactive bladder restores the abnormal levels of overactive bladder markers (Serefko et al., 2025). Here, HCRTR2 is linked to overactive bladder.