Giving further support to this hypothesis, in a recent observational study including 150 patients with T1DM and 100 patients with T2DM, in which VCTE was used to detect MASLD, De Vries et al.29reported that both in patients with T1DM and in those with T2DM, waist circumference, BMI and metabolic syndrome were positively associated with MASLD while estimated insulin sensitivity (eGDR) was negatively associated with MASLD, even after adjustment for age, sex and diabetes duration. This evidence concerns the gene INS and metabolic syndrome.