For 25 biomarkers (including 17 biochemical indices, four inflammatory cytokines, and four biomarkers of immunity and inflammation), MR studies provided suggestive evidence that 16 biochemical indices and inflammatory cytokines (e.g., 1-standard deviation [SD] increase in lipoprotein(a) [Lp(a)] concentrations and thyrotropin [TSH], elevated interleukin [IL]10 and IL1ra) were associated with a reduced risk of AD, whereas nine biomarkers (e.g., glycoprotein acetyls, CD4 count, MIP-1b, C-reactive protein (CRP), and CD 33) were associated with a high risk of AD. The gene discussed is CD4; the disease is Alzheimer disease.