TNC and cancer: These genes of interest are ANGPT1, ANGPTL4, CTHRC1, CXCL1, CXCL5, CXCL6, CXCL8, FST, NRCAM, SAA1, SAA2, SRPX2, STC2, TFPI2, TGFB2, TNC and VCAN. In OC, for example, most of these genes are highly expressed by carcinoma-associated fibroblasts (CAFs) [36], which are crucial components within the TME of most cancers [60].