Pearson correlation of the ex vivo response to PF-3758309 with the activity, phosphorylation of kinases or proteins targeted by this compound in a set of primary blast from 36 AML cases [14] revealed that the activities of PAK1, RPS6KA1, RPS6KA3 and others are elevated in sensitive primary AML cases (Fig. 7A-C). Here, RPS6KA3 is linked to acute myeloid leukemia.