FLT3 and acute myeloid leukemia: Consistent with this conclusion, the FLT3-ITD positive cell lines (MV4-11 and MOLM-13) were the most sensitive to PF-3758309 across a panel of 9 AML cell lines, highlighting the relevance of the off-target effect of PF-3758309 on FLT3-ITD mutant cells.