Notably, Heparanase, which degrades HS (Hulett et al. 1999; Kussie et al. 1999) and is downregulated by p53 (Baraz et al. 2006), is highly expressed in tumor cells (Vlodavsky et al. 1999; Kosir et al. 1999). The gene discussed is TP53; the disease is neoplasm.