EGF and cancer: ACAP4 regulates membrane–cytoskeletal dynamics in response to a variety of stimuli such as EGF (Fang et al., 2006; Song et al., 2018) and histamine (Ding et al., 2010; Yuan et al., 2017) and is implicated in cancer cell migration and invasion (Okabe et al., 2004; Ha et al., 2008; Song et al., 2018; Mullen et al., 2021).