Previous studies have shown that nitazoxanide can reverse drug resistance and inhibit the proliferation of colorectal cancer cells by downregulating the Wnt–β-catenin signaling pathway and reducing the expression of MYC and CCND1. These findings indicate that the Wnt-β-catenin signaling pathway plays an important role in tumor development and drug resistance development45. Here, CCND1 is linked to colorectal cancer.