The results revealed that activator protein-1 (AP-1) family members, including JUN, FOS, MAF and ATF subfamily members, were notably enriched in both the H3K23su GAIN and LOSS regions (Fig. 2c and Supplementary Fig. 7b), which preferentially bind to the DNA sequence 5′-TGACTCA-3′ and play critical roles in various cellular activities and cancer development36,38,39. This evidence concerns the gene JUN and cancer.