Moreover, relatively high coexpression scores were also observed for FOSL2/KLF6, FOSL2/RUNX2 and GRHL2/FOXA1 (Fig. 4b), suggesting that the DETFs related to H3K23su DERs might work together and be responsible for 5-FU resistance in HCT15 colon cancer cells. Here, GRHL2 is linked to malignant colon neoplasm.