Although the inhibitory effects of YAP1S127A co-expression in SCLC-A cells and of ASCL1 or YAP1S127A co-expression in SCLC-N cells were validated by a cell viability assay in H2107SCLC-A and H82SCLC-N cells, respectively, co-expression of NEUROD1 with ASCL1 in H2107SCLC-A cells did not result in a significant decrease in cell viability (Supplementary Fig. 3a). Here, ASCL1 is linked to small cell lung carcinoma.