RB1 and small cell lung carcinoma: First, we characterized p53 and Rb expression patterns (Supplementary Fig. 1a) in a total of 151 surgically treated human SCLC tumors and found that 95.2% and 90.7% of the tumors had inactivated p53 (Supplementary Fig. 1b) and inactivated Rb (Supplementary Fig. 1c) patterns, respectively.