We previously showed that pharmacological inhibition or genetic deletion of IL-12/IL-23 signaling reversed cognitive deficits in aged APPPS1 mice7, suggesting that—based on the herein-presented identification that IL-12, but not IL-23, is key in AD-associated IL-12/IL-23 signaling—neuronal homeostasis is affected by IL-12 signaling. Here, IL23A is linked to Cognitive impairment.