When investigating the effects of IL-12 signaling on neurons at the transcriptome level, we also found a reduced number of neurons within the subiculum in AD-like APPPS1 mice compared to WT littermates (which did not reach significance) as well as alterations in the gene expression of subicular neurons of APPPS1 mice lacking Il12b compared to APPPS1 mice with functional IL-12 signaling (Extended Data Fig. 6a,b). The gene discussed is IL12B; the disease is Alzheimer disease.