This is reflected by distinct transcriptome profiles of WT versus APPPS1 mice including an AD-specific upregulation of microglial pro-inflammatory genes, such as Il12b and Clec7a (Extended Data Fig. 3b,c)—a phenotype that was largely reverted upon deleting Il12b in APPPS1 mice (Extended Data Fig. 3d). This evidence concerns the gene CLEC7A and Alzheimer disease.