As the genetic repertoire for IL-12 signaling, namely IL12RB1 and IL12RB2 transcripts, is also present in neurons and oligodendrocytes in postmortem human primary motor cortex according to the Allen Brain Map, and because we found IL-12 receptor transcripts, but not those for IL-23 receptor, in postmortem hippocampi of human AD and control patients, the CNS IL-12/IL-23 signaling repertoire seems to be similar in mice and humans. Here, IL23R is linked to Alzheimer disease.