IL23A and Alzheimer disease: To dissect whether IL-12 and/or IL-23 is driving the previously reported IL-12/IL-23/p40-mediated modulation of AD pathology in the amyloidogenic mouse brain7 on a functional level, we bred AD-like APPPS1 to mice in which either the IL-12-specific receptor or the IL-23-specific receptor can be deleted conditionally, namely Il12rb2fl/fl or Il23rfl/fl mice, resulting in APPPS1.Il12rb2fl/fl or in APPPS1.Il23rfl/fl mice.