Close-ups of the astrocyte populations in both AD-related genotypes, namely in APPPS1 and APPPS1.Il12b−/− mice, showed an equally Aβ-reactive, Gfap-enriched inflammatory astrocyte cluster, suggesting that the lack or presence of p40 does not alter the astrocytic phenotype in the amyloidogenic CNS (Extended Data Fig. 3e–h). The gene discussed is IL12B; the disease is Alzheimer disease.