IL12B and Alzheimer disease: Because microglia have a strong impact on neuroinflammation and AD pathology, we assessed transcriptional changes in microglia from APPPS1 mice with and without genetic ablation of Il12b. We observed two microglia clusters (Fig. 7a), one of which was prominent in both APPPS1 and APPPS1.Il12b−/− mice—that is, AD specific but virtually absent in age-matched WT mouse brains.