GFAP and Alzheimer disease: Close-ups of the astrocyte populations in both AD-related genotypes, namely in APPPS1 and APPPS1.Il12b−/− mice, showed an equally Aβ-reactive, Gfap-enriched inflammatory astrocyte cluster, suggesting that the lack or presence of p40 does not alter the astrocytic phenotype in the amyloidogenic CNS (Extended Data Fig. 3e–h).