In view of significantly increased IL-12p70 protein levels in AD brains compared to non-demented control cases, where higher Braak stages—indicative of a stronger cognitive decline—correlated with higher IL-12p70 protein expression, and given the profound response of human oligodendrocyte-like cells to IL-12 stimulation in vitro—in contrast to IL-23, which showed almost no effects—IL-12 appears to be an attractive and obvious druggable target in AD. This evidence concerns the gene IL23A and Mental deterioration.