SEZ6 and Alzheimer disease: In addition to seeing some differential regulation of genes involved in ion homeostasis, we also found an upregulation of genes implicated in dendrite development (Dab1, Fat3, Fezf2, Fmn1, Hecw2, Klhl1, Map1b, Nedd3l, Sez6 and Ss181) in APPPS1.Il12b−/− mice compared to APPPS1 mice, suggesting IL-12-dependent enhanced compensatory efforts aimed at regenerating neuronal homeostasis in the AD microenvironment (Fig. 6c).