MYCN has been implicated as a potential factor in the immune suppressive, or “cold” phenotype, in NB 3,14 as MYCN amplification correlates with low immune infiltrate signatures 13, lower amounts of NK-T cells and CD8+ T cells in tumors by mRNA expression 15, and lower amounts of MHC-I gene expression in tumors 16. This evidence concerns the gene CD8A and neuroblastoma.