In ovarian clear cell carcinoma (OCCC) upon shRNA mediated knockdown of ARID1A, there was marked limited chromatin accessibility around interferon response factor I (IRF1) and IRF2 binding motifs leading to impaired gene expression and protein secretion of signaling chemokines CXCL9 and CXCL10 after interferon-gamma (IFNγ) treatment 26. The gene discussed is IFNG; the disease is ovarian clear cell cancer.