LRP1B, a common tumor suppressor in solid tumors, could influence infiltration of immune cells, and its mutation correlated with poor prognosis in gastric cancer.35–38 The PI3K pathway, involved in key cancer hallmarks, regulated the tumor immune microenvironment.39,40 In dMMR/MSI-H gastric cancer, PI3K pathway mutations correlated with lower immune cell infiltration and poorer outcomes.41 These findings suggested that modifications in the intrinsic characteristics of tumor cells may potentially modulate the response to treatment by influencing the TME. The gene discussed is LRP1B; the disease is gastric cancer.