Lymphocytes including CD3+ T, CD4+ T, CD8+ T cells, and CD20+ B cells were mainly distributed in the stroma region, but myeloid cells such as CD66+ neutrophils, CD68+ macrophages were located more in the tumor parenchyma, highlighting the particular distribution of tumor-infiltrating immune cells in AFP-G/GEJ adenocarcinoma (supplementary Fig. 10). This evidence concerns the gene CD8A and gastroesophageal junction adenocarcinoma.