Additionally, TLSs were identified in 14 cases (46.6%), a rate considerably lower than the prevalence of TLSs observed in AFP-negative GC.23,24 These observations suggest that the TME of AFP-G/GEJ adenocarcinoma may be “colder” than that of AFP-negative gastric adenocarcinoma. Here, AFP is linked to gastroesophageal junction adenocarcinoma.