MYC and malignant colon neoplasm: Recent studies have highlighted the central role of eRNAs in regulating enhancer-promoter interactions, contributing to tumor development and progression.36 For example, Li et al. demonstrated that eRNAs reinforce estrogen-dependent enhancer–promoter looping in breast cancer cells,37 while CCAT1, an eRNA associated with colon cancer, was shown to enhance c-MYC expression.38 Despite growing interest in eRNAs, their specific roles in prostate cancer have remained largely unexplored.