Ferroptosis is an emerging target in cancer therapy due to its reliance on iron-dependent lipid peroxidation, a pathway that is heavily influenced by iron metabolism.31,39 The role of LTF in ferroptosis is particularly intriguing given its dual functions in iron regulation and oxidative stress response.40 LTF encodes lactotransferrin, an iron-binding protein involved in iron transport and storage, which is critical for maintaining cellular iron balance. The gene discussed is LTF; the disease is cancer.