Elevated LTF expression increases the labile iron pools, creating a cellular environment conductive to ferroptosis through heightened lipid peroxide generation.40 This study is the first to implicate an eRNA in ferroptosis regulation, demonstrating that LTFe promotes ferroptosis by upregulating LTF.31,40 By enhancing LTF expression, LTFe increases intracellular iron levels and lipid reactive oxygen species (LipROS), sensitizing prostate cancer cells to ferroptosis. The gene discussed is LTF; the disease is prostate cancer.