Furthermore, a study using the Rotterdam cohort reported no cross-sectional associations between self-rated sleep, actigraphy-estimated sleep and 24-hour activity rhythms and NfL, Aβ40, Aβ42, and total-tau in dementia-free subjects (age: 72 ± 8 years, total sample n = 4712, actigraphy sample n = 849) [58]. Here, MAPT is linked to dementia.