TREM2 and Alzheimer disease: This result is in line with a recent study demonstrating that TREM2 shedding in human iPSC-derived microglia partly depends on TSPAN14 (Yang et al, 2023), a recently identified AD risk gene, which is suggested to act as a non-proteolytic subunit of an ADAM10 protease complex (Kleinberger et al, 2014; Harrison et al, 2021; Schwartzentruber et al, 2021; Bellenguez et al, 2022; Yang et al, 2023).