Increased iRhom2 expression is associated with enhanced AD risk (De Jager et al, 2014; Lunnon et al, 2014; Lardenoije et al, 2019; Li et al, 2020; Palma-Gudiel et al, 2023) and may lead to augmented iRhom2-dependent TREM2 shedding. Here, TREM2 is linked to Alzheimer disease.