This is aberrantly augmented by the TREM2 H157Y variant, located directly at the TREM2 cleavage site, which enhances TREM2 shedding and increases the risk for AD (Jiang et al, 2016; Feuerbach et al, 2017; Schlepckow et al, 2017; Thornton et al, 2017). The gene discussed is TREM2; the disease is Alzheimer disease.