Consequently, several agonistic TREM2-targeted antibodies are in preclinical and clinical development for AD, which bind TREM2 close to its cleavage site and reduce TREM2 shedding (Wang et al, 2020; Schlepckow et al, 2023; van Lengerich et al, 2023). The gene discussed is TREM2; the disease is Alzheimer disease.