Its impairment in the RPE results in the buildup of harmful aggregates that lead to damage of the outer retina, a process observed in conditions such as Stargardt disease and choroideremia,90 as well as in LSD caused by CLN3 pathogenic variants, where patient-derived iPSC-RPE lines exhibit disrupted POS phagocytosis.20 This evidence concerns the gene CLN3 and choroideremia.