CDKN1A and cancer: The interactions of TP53 and MAPK14 have been previously characterized as they regulate autophagy, a process that allows cancer cells to resist drug and radiation therapies.77TP53 is also overexpressed in tumors lacking MAPK14, while high levels of MAPK14 have been found in advanced stages of gastric cancer.78 The senescence marker CDKN1A is downregulated by the KOs of IRAK1 (LFC: −0.61, Q: 0.008) or NFKBIA (LFC: −0.46, q: 0.07) in the presence of an immune neighbor but upregulated by these KOs in the absence of one (respectively LFC: 0.59, Q: 0.06 and LFC: 0.23, Q: 0.5).