The KOs of IRAK1, LBP, or TAB2 in the tumor cells had strongly correlated effects on T cell gene expression, each downregulating activation markers like TNFRSF9 (LFC: −0.33 and Q: 0.08, LFC: −0.4 and Q: 0.02, LFC: −0.5 and Q: 0.006, respectively) and ZBED2 (LFC: −0.24 and Q: 0.16, LFC: −0.31 and Q: 0.05, and LFC: −0.4 and Q: 0.02, respectively). Here, TAB2 is linked to neoplasm.