They include (1) sociodemographic variables (ie, age at evaluation and gender), (2) clinical variables (ie, age at cancer diagnosis, intrathecal chemotherapy, intrathecal methotrexate dose, IV high-dose methotrexate, and inflammatory interleukin-8 levels), and (3) socioenvironmental and lifestyle variables (ie, sleep, fatigue, physical activity, and family functioning). Here, CXCL8 is linked to cancer.