The clinical historyincludes growth deficiency, primary amenorrhea, hypogonadism, and hypothyroidism.Since adolescence, she was in continuous use of levothyroxine(Euthyrox® 75 mcg/day), testosterone(Deposteron® 25 mg once every 28 days), conjugated naturalestrogens (Premarin® 0.3 mg every other day), growth hormone (GH 4IU/day) and prednisone (Meticorten® 2.5 mg every other day).Menarche was induced by medical treatment at 19 years of age and pubarche andthelarche occurred simultaneously with menarche. This evidence concerns the gene GH1 and hypogonadism.