It is highly expressed in the brain and associated with the neurologic disorder Huntington's disease.34,35 In cancer, it has been found that the expression of UBE2K is increased in hepatocellular carcinoma (HCC), and recently it was shown that UBE2K promotes progression of HCC.36 UBE2K seems to play an essential role in the regulation of cancer cell cycles and may be a target for anticancer therapy.36-39 The potential role of UBE2K in BRAF V600E-mutated cancer needs further investigation. This evidence concerns the gene UBE2K and juvenile Huntington disease.