Previous research demonstrated that both Vif and Vpr expression causes cell cycle arrest and cytotoxicity in CD4 +T cells and as well as many cancer cell lines (Augustine et al., 2017; Emerman, 1996; Evans et al., 2018; Nagata et al., 2020; Sakai et al., 2011; Sakai et al., 2006; Salamango et al., 2019; Salamango et al., 2020; Wang et al., 2011; Wang et al., 2008). This evidence concerns the gene CD4 and cancer.