Certain cytokines, particularly IL-1 \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β and granulocyte–macrophage colony-stimulating factor, further stimulate the proliferation and differentiation of TET2-mutated HSPCs into myeloid lineages, skewing hematopoiesis toward myeloid bias, which is a characteristic feature of CH [44]. This evidence concerns the gene TET2 and cyclic hematopoiesis.