CHIP is a specific form of CH characterized by somatic mutations in leukemia driver genes with a variant allele fraction (VAF) of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\ge$$\end{document}≥ 2% in individuals without diagnosed blood disorders or cytopenia [3] [7]. Here, STUB1 is linked to cyclic hematopoiesis.