AD hallmarks include the accumulation of senile plaques and intraneuronal neurofibrillary tangles, resulting from extracellular deposition of the amyloid beta (Aβ) peptide (Glenner & Wong 1984) and intracellular accumulation of hyperphosphorylated tau (Goedert et al. 1992), respectively. Here, MAPT is linked to Alzheimer disease.