Literature-based network analysis of those 537 overlapping DEGs in JDM L and NL skin compared with CTL highlighted increased mRNA expression of BGLAP, encoding osteocalcin, a bone matrix protein potentially involved in calcinosis, as well as CASP1, which can activate IL1B and IL18 in the proper context (Figure 1B). The gene discussed is BGLAP; the disease is calcinosis.