GATA6 and pancreatic agenesis: GATA6 is required for the development of multiple mesoderm and endoderm-derived organs, and some CHD patients with heterozygous GATA6 mutations have comorbidities including pancreatic agenesis, neonatal diabetes, or congenital diaphragmatic hernia (Gong et al., 2013; Yu et al., 2014).